YearToAvoid

2022 Mercedes-Benz E350 Reliability Data: Problems & Recalls

Best The 2022 Mercedes-Benz E350 has a complaint index of 11, the second-lowest among 19 model years, earning a Best verdict. NHTSA lists 8 complaints and 3 recalls, with no crashes, fires, injuries, or deaths reported.

Based on NHTSA complaints per model-year, not a reliability rating. Methodology

YearToAvoid Scorecard

Complaint Index
11/100
#17 of 19 E350 years
Verdict
Best
vs. other years of this model
Complaints
8
unique NHTSA reports
Recalls
3
distinct NHTSA campaigns
Crashes
0
reported in complaints
Fires
0
Injuries
0
Top issue
Collision Avoidance & Cameras
Best nearby year
2024
rated Best
NHTSA overall rating
Not rated
EPA combined MPG
25
22 city / 30 hwy
Injuries / deaths
0 / 0

Top 2022 Mercedes-Benz E350 problems

Share of this year’s NHTSA complaints by component group. Groups with 15+ complaints have their own page.

  1. Other3 (38%)
  2. Collision Avoidance & Cameras2 (25%)
  3. Electrical System1 (13%)
  4. Engine1 (13%)
  5. Fuel System1 (13%)
  6. Transmission & Powertrain1 (13%)
  7. Visibility & Wipers1 (13%)

A complaint can list more than one component, so shares add up to more than 100%. Shares are % of complaints.

What owners report

  • Vehicle unexpectedly decelerates while the accelerator pedal remains depressed, sometimes with a warning light on, traced by the dealer to a fuel pump failure.
  • Automatic emergency braking has activated on its own during traffic with no obstruction present.
  • Automatic headlamp mode has turned inoperative and then intermittently returns without driver input.
  • The system displaying speed limits abruptly drops the reading and causes the vehicle to slow itself sharply in dense highway traffic.
  • A crack has appeared across the front glass roof panel above the windshield while the vehicle was parked, with no known impact.
2022 Mercedes-Benz E350 complaints: complaints filed per month1Aug 2023Sep 2023Dec 2023Jan 2024Jun 2024Oct 2025Jan 2026Jul 2026
8 complaints filed with NHTSA from Aug 2023 to Jul 2026; peak Aug 2023 (1).

2022 Mercedes-Benz E350 recalls

3 NHTSA recall campaigns list this model year.

  1. NHTSA 23V880000Dec 21, 2023Fuel System79,676 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024, August 9, 2024, October 1, 2024, and December 2, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of NHTSA recall number 23V-445.

  2. NHTSA 23V445000Jun 26, 2023Fuel System143,551 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

  3. NHTSA 22V189000Mar 25, 2022Steering8,396 vehicles

    Steering: steering wheel/handle bar

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.

    Risk: Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.

    Remedy: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.

2022 Mercedes-Benz E350 fuel economy and fuel cost

City
22 MPG
Highway
30 MPG
Combined
25 MPG
Annual fuel cost (EPA)
$3,175
15,000 mi/yr
Fuel
Premium
Current regular gas
$4.32/gal
national avg.

EPA figures; median across configurations of this model year. Estimate your own cost with the fuel cost calculator.

2022 compared with other E350 years

Complaint Index by model year (0 = fewest issues, 100 = most)0255075100’05’06’07’08’09’10’11’12’13’14’15’16’17’20’21’22’23’24’25
Complaint Index: 0 = fewest issues, 100 = most, relative to other years of this model. Avoid Caution Good Best
YearVerdictIndexComplaintsRecallsMPG
2020Good398625.5
2021Caution22131225
2022Best118325
2023Good286325
2024Best65427

All Mercedes-Benz E350 years: best and worst →

Frequently asked questions

Is the 2022 Mercedes-Benz E350 reliable?
Based on NHTSA owner complaints and recalls, the 2022 E350 ranks well among E350 model years, with a complaint index of 11 and only 8 complaints logged, earning a Best verdict relative to other years.
What problems does the 2022 Mercedes-Benz E350 have?
The top reported problem area is Collision Avoidance & Cameras, followed by isolated reports involving the electrical system, engine, fuel system, transmission, and visibility/wipers. One fuel system complaint noted median mileage of 14,403.
Does the 2022 Mercedes-Benz E350 have any recalls?
NHTSA lists 3 recalls for the 2022 E350: two fuel pump replacement campaigns and one software update for the DISTRONIC hand detection control unit. None are do-not-drive recalls.
How does the 2022 E350 compare to other E350 years?
The 2022 E350 has a complaint index of 11, ranked 17th worst (meaning near the best) out of 19 model years, well below high-complaint years like 2006 (index 100) and 2014 (index 94).
What is the fuel economy of the 2022 Mercedes-Benz E350?
EPA rates the 2022 E350 at 25 mpg combined (22 city / 30 highway), with an estimated annual fuel cost of $3,175.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.