YearToAvoid

2022 Mercedes-Benz E350 Problems, Recalls & Reliability

Verdict

Best

Complaint Index

0/100

#14 most-complained of 14 E350 years

The 2022 Mercedes-Benz E350 ranks Best among 14 model years, with a complaint index of 0 and just 8 NHTSA complaints. It has 3 recalls covering fuel system and steering software, but no crashes, fires, or injuries reported.

Complaints
8
Recalls
3
Crashes / fires
0 / 0
Injuries / deaths
0 / 0
NHTSA overall rating
Not rated
EPA combined MPG
25
22 city / 30 hwy

Top 2022 Mercedes-Benz E350 problems

NHTSA owner complaints by component group. Groups with 15+ complaints have their own page.

  1. Other3 (38%)
  2. Collision Avoidance & Cameras2 (25%)
  3. Electrical System1 (13%)
  4. Engine1 (13%)
  5. Fuel System1 (13%)
  6. Transmission & Powertrain1 (13%)
  7. Visibility & Wipers1 (13%)

What owners report

  • Some owners report sudden deceleration while driving at various speeds, with the accelerator pedal still depressed, traced to a fuel pump failure at a median mileage of 14,403.
  • Owners describe the automatic braking system activating suddenly in traffic with no obstruction present.
  • Some report the automatic headlamp mode turning on and off intermittently.
  • One owner described the vehicle repeatedly and abruptly lowering the displayed speed limit and slowing itself down in dense highway traffic.
  • A front glass roof panel above the windshield was reported to develop a large crack while the vehicle was parked, with no known impact.
2022 Mercedes-Benz E350 complaints: complaints filed per month2Aug 2023Sep 2023Dec 2023Jan 2024Jun 2024Oct 2025Jan 2026Jul 2026
10 complaints filed with NHTSA from Aug 2023 to Jul 2026; peak Jan 2024 (2).

2022 Mercedes-Benz E350 recalls

3 NHTSA recall campaigns list this model year.

  1. NHTSA 23V880000Dec 21, 2023Fuel System79,676 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024, August 9, 2024, October 1, 2024, and December 2, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of NHTSA recall number 23V-445.

  2. NHTSA 23V445000Jun 26, 2023Fuel System143,551 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

  3. NHTSA 22V189000Mar 25, 2022Steering8,396 vehicles

    Steering: steering wheel/handle bar

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.

    Risk: Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.

    Remedy: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.

2022 Mercedes-Benz E350 fuel economy and fuel cost

City
22 MPG
Highway
30 MPG
Combined
25 MPG
Annual fuel cost (EPA)
$3,175
15,000 mi/yr
Fuel
Premium
Current regular gas
$4.32/gal
national avg.

EPA figures; median across configurations of this model year. Estimate your own cost with the fuel cost calculator.

2022 compared with other E350 years

Complaint Index by model year (0 = fewest issues, 100 = most)0255075100’10’11’12’13’14’15’16’17’20’21’22’23’24’25
Complaint Index: 0 = fewest issues, 100 = most, relative to other years of this model. Avoid Caution Good Best
YearVerdictIndexComplaintsRecallsMPG
2020Good318625.5
2021Best23131225
2022Best08325
2023Good466325
2024Best85427

All Mercedes-Benz E350 years: best and worst →

Frequently asked questions

Is the 2022 Mercedes-Benz E350 reliable?
Based on NHTSA owner complaints and recalls, the 2022 E350 ranks Best among 14 model years, with only 8 complaints and a complaint index of 0.
What problems does the 2022 Mercedes-Benz E350 have?
NHTSA lists complaints in Collision Avoidance & Cameras, Electrical System, Engine, Fuel System, Transmission & Powertrain, and Visibility & Wipers, each with only 1-2 complaints.
Does the 2022 Mercedes-Benz E350 have any recalls?
Yes, NHTSA lists 3 recalls for the 2022 E350: two involving the fuel pump and one involving a steering wheel hand-detection software update for DISTRONIC. None are do-not-drive recalls.
How does the 2022 E350 compare to other years?
The 2022 E350 has a complaint index of 0 and ranks 14th out of 14 model years from worst to best, making it one of the strongest years, alongside 2017, 2021, and 2024, which are also rated Best.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.