YearToAvoid

2021 Lexus RX350 Reliability Data: Problems & Recalls

No verdict The 2021 Lexus RX350 has a low complaint index of 11 and ranks 17th out of 19 model years for reported problems, meaning it's one of the more trouble-free years. NHTSA lists just 1 complaint and 1 recall for a fuel system transport hook issue.

Based on NHTSA complaints per model-year, not a reliability rating. Methodology

YearToAvoid Scorecard

Complaint Index
11/100
#17 of 19 RX350 years
Verdict
No verdict
vs. other years of this model
Complaints
1
unique NHTSA reports
Recalls
1
distinct NHTSA campaigns
Crashes
0
reported in complaints
Fires
0
Injuries
0
Top issue
Structure & Body
Best nearby year
2020
rated Best
NHTSA overall rating
5 / 5 ★
EPA combined MPG
22
19 city / 26 hwy
Injuries / deaths
0 / 0

Top 2021 Lexus RX350 problems

Share of this year’s NHTSA complaints by component group. Groups with 15+ complaints have their own page.

  1. Other1 (100%)
  2. Structure & Body1 (100%)

A complaint can list more than one component, so shares add up to more than 100%. Shares are % of complaints.

What owners report

  • Driver side door has opened unexpectedly while the vehicle was being driven on the highway.
  • The door opened even though it had been fully closed before the drive began.
  • No warning lights or audible alarms activated before or during the door opening event.

2021 Lexus RX350 recalls

1 NHTSA recall campaign list this model year.

  1. NHTSA 21V043000Feb 3, 2021Fuel System1,081 vehicles

    Fuel system, gasoline:storage:tank assembly:filler pipe and cap

    Toyota Motor Engineering & Manufacturing (Lexus) is recalling certain 2019 Lexus RX350 and 2021 RX350 vehicles. The transport hook may not have been removed prior to sale. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 301, "Fuel System Integrity."

    Risk: During a rear-end crash, the transport hook can damage the fuel filler pipe, increasing the risk of a fire.

    Remedy: Lexus will notify owners, and dealers will inspect and, as necessary, remove the rear transport hook, free of charge. The recall began April 1, 2021. Owners may contact Lexus customer service at 1-800-331-4331. Lexus' number for this recall is 21LA01.

2021 Lexus RX350 fuel economy and fuel cost

City
19 MPG
Highway
26 MPG
Combined
22 MPG
Annual fuel cost (EPA)
$2,950
15,000 mi/yr
Fuel
Regular
Current regular gas
$4.32/gal
national avg.

EPA figures; median across configurations of this model year. Estimate your own cost with the fuel cost calculator.

2021 compared with other RX350 years

Complaint Index by model year (0 = fewest issues, 100 = most)0255075100’05’06’07’08’09’10’11’12’13’14’15’16’17’18’19’20’21’22’23
Complaint Index: 0 = fewest issues, 100 = most, relative to other years of this model. Avoid Caution Good Best
YearVerdictIndexComplaintsRecallsMPG
2019Good4431322
2020Best177122
2021No verdict111122
2022Good3910022
2023No verdict224124.5

All Lexus RX350 years: best and worst →

Frequently asked questions

Is the 2021 Lexus RX350 reliable based on NHTSA data?
Yes. It has a complaint index of 11, one of the lowest among the 19 RX350 model years covered, ranking 17th out of 19 for reported problems.
Does the 2021 Lexus RX350 have any recalls?
Yes, one recall (campaign 21V043000) for a rear transport hook that may not have been removed before sale, which affects fuel system compliance.
What is the main complaint about the 2021 Lexus RX350?
NHTSA lists only one complaint, involving a driver side door that opened unexpectedly while the vehicle was being driven, reported at 60 miles.
How does the 2021 RX350 compare to other RX350 years?
With a complaint index of 11, the 2021 model ranks near the bottom of the 19 model years for complaints, well below years like 2010 (complaint index 100) and 2007 (complaint index 94).
What is the fuel economy of the 2021 Lexus RX350?
The EPA rates it at 22 mpg combined (19 city / 26 highway), with an estimated annual fuel cost of $2,950.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.