2010 Mercedes-Benz E350 Engine Problems
NHTSA lists 20 engine complaints for the 2010 Mercedes-Benz E350, 11% of all complaints filed for the year, with a median failure mileage of 49,884 miles. A related recall (22V168000) addresses incorrect software on engine control units.
- Engine complaints
- 20
- 11% of 183 complaints
- All complaints this year
- 183
- Crashes reported
- 3
- Fires reported
- 0
- Injuries reported
- 3
- Median mileage
- 49,884 mi
- Related recalls
- 1
Typical engine symptoms owners report
- Owners describe check engine lights that cycle on and off for days at a time, sometimes traced to a faulty camshaft adjuster solenoid.
- Cold-start knocking noise from the engine lasting several seconds before quieting down.
- Sudden loss of power while accelerating that puts the car into limp mode, described as dangerous in highway traffic.
- Unexpected engine shaking paired with an illuminated check engine light shortly after starting the vehicle.
- Reports of gear or transmission noise appearing at relatively low mileage.
When 2010 Mercedes-Benz E350 engine complaints were filed
First complaint Oct 28, 2009, latest Jul 24, 2025.
Engine recalls for the 2010 Mercedes-Benz E350
- NHTSA 22V168000Mar 18, 2022Engine22 vehicles
Engine and engine cooling:engine:engine control module (ecu/ECM):software
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2010 E350, 2014 G550, 2008-2009 C300, 2008 C350, 2009 CLK550, 2007 SL550, SLK280, and 2008 SLK350 vehicles. Various control units may have been updated with incorrect software configuration during a service repair. This can result in various system failures, such as loss of drive power, reduced exterior lighting, or loss of dynamic control functions, including stability and traction control.
Risk: Various system failures, such as loss of drive power, reduced exterior lighting, or loss of dynamic control functions including stability and traction control, can increase the risk of a crash.
Remedy: Dealers will update the software configuration on the affected control units, free of charge. Owner notification letters were mailed May 3, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040003.
Engine complaints by E350 model year
Raw complaint counts per model year; newer years have had less time to accumulate complaints.
Frequently asked questions
- How many engine complaints does NHTSA have for the 2010 Mercedes-Benz E350?
- NHTSA lists 20 engine complaints for the 2010 E350, which is 11% of the 183 total complaints filed for that model year.
- Is there a recall related to engine problems on the 2010 E350?
- Yes. Recall campaign 22V168000, reported in 2022, covers the 2010 E350 among other Mercedes-Benz models for control units that may have been updated with incorrect software.
- At what mileage do engine problems typically show up on the 2010 E350?
- NHTSA data shows a median mileage of 49,884 miles at the time of engine-related failure.
- Did the 2010 E350 engine issues cause any crashes or injuries?
- NHTSA records show 3 crashes and 3 injuries among the complaints filed in this area for the 2010 E350.