YearToAvoid

2006 Mercedes-Benz E350 Engine Problems

NHTSA has 77 owner complaints about engine problems in the 2006 Mercedes-Benz E350, 19% of all 399 complaints for this model year. That is the highest engine complaint count among 19 E350 model years. These complaints report 7 crashes, 4 fires, and 13 injuries. Median mileage at failure: 87,000 miles.

Engine complaints
77
19% of 399
Crashes reported
7
Fires reported
4
Injuries reported
13
Median mileage
87,000 mi
Related recalls
0

When 2006 Mercedes-Benz E350 engine complaints were filed

First complaint Oct 10, 2006, latest Aug 29, 2024.

2006 Mercedes-Benz E350 engine complaints: complaints filed per quarter62006 Q42010 Q32012 Q12014 Q32016 Q32018 Q22021 Q1
77 complaints filed with NHTSA from 2006 Q4 to 2024 Q3; peak 2014 Q4 (6).

Engine recalls for the 2006 Mercedes-Benz E350

No safety recalls on record for this model year.

Engine complaints by E350 model year

Raw complaint counts per model year; newer years have had less time to accumulate complaints.

  1. 20050 (0%)
  2. 200677 (19%)
  3. 200735 (10%)
  4. 200818 (10%)
  5. 20095 (8%)
  6. 201020 (11%)
  7. 201117 (8%)
  8. 201221 (10%)
  9. 201324 (15%)
  10. 201425 (9%)
  11. 20152 (6%)
  12. 201610 (20%)
  13. 20173 (43%)
  14. 20203 (38%)
  15. 20214 (31%)
  16. 20221 (13%)
  17. 20230 (0%)
  18. 20242 (40%)
  19. 20251 (50%)

Frequently asked questions

Does the 2006 Mercedes-Benz E350 have engine problems?
NHTSA has 77 owner complaints about the engine in the 2006 Mercedes-Benz E350, 19% of all complaints for this model year, including 7 that report a crash. Median mileage at failure is 87,000 miles.
Which Mercedes-Benz E350 year has the most engine complaints?
The 2006 Mercedes-Benz E350 has the most engine complaints (77), compared with 77 for the 2006.
Is there a engine recall for the 2006 Mercedes-Benz E350?
No NHTSA recall campaign for the 2006 Mercedes-Benz E350 is classified under engine. Complaints alone do not trigger a recall; check the full recall list and your VIN.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.