YearToAvoid

2022 Mercedes-Benz E 450 Reliability Data: Problems & Recalls

Good The 2022 Mercedes-Benz E 450 has a complaint index of 40, ranking 4th out of 6 model years, and carries a Good verdict. It has 11 complaints and 5 recalls, with Electrical System issues the top concern (36% of complaints).

Based on NHTSA complaints per model-year, not a reliability rating. Methodology

YearToAvoid Scorecard

Complaint Index
40/100
#4 of 6 E 450 years
Verdict
Good
vs. other years of this model
Complaints
11
unique NHTSA reports
Recalls
5
distinct NHTSA campaigns
Crashes
0
reported in complaints
Fires
0
Injuries
0
Top issue
Electrical System
Best nearby year
—
no alternative with data
NHTSA overall rating
Not rated
EPA combined MPG
24.5
22 city / 29 hwy
Injuries / deaths
0 / 0

Top 2022 Mercedes-Benz E 450 problems

Share of this year’s NHTSA complaints by component group. Groups with 15+ complaints have their own page.

  1. Electrical System4 (36%)
  2. Fuel System3 (27%)
  3. Brakes2 (18%)
  4. Suspension, Wheels & Tires2 (18%)
  5. Engine1 (9%)
  6. Collision Avoidance & Cameras1 (9%)
  7. Steering1 (9%)
  8. Structure & Body1 (9%)
  9. Transmission & Powertrain1 (9%)

A complaint can list more than one component, so shares add up to more than 100%. Shares are % of complaints.

What owners report

  • Automatic emergency braking has triggered unexpectedly at low speed, slamming on the brakes for objects like a small road plate or a tree shadow.
  • The 48-volt electrical system has failed while driving, sometimes with a loud popping sound from the engine compartment followed by a total loss of power.
  • The backup camera has failed to display any image when the car is shifted into reverse.
  • Owners waiting on the fuel pump recall (23V445000) reported the replacement part was unavailable for months despite repeated dealer visits.
  • An underbody splash shield covering the transmission has detached at highway speed, causing noise and dragging debris.
  • A dashboard warning for '48 voltage battery malfunction' has appeared repeatedly, followed by a red warning light and a brief window to pull over before power loss.
2022 Mercedes-Benz E 450 complaints: complaints filed per month2Apr 2022Aug 2022May 2023Nov 2023Dec 2024
11 complaints filed with NHTSA from Apr 2022 to Mar 2026; peak Sep 2023 (2).

2022 Mercedes-Benz E 450 recalls

5 NHTSA recall campaigns list this model year.

  1. NHTSA 24V100000Feb 9, 2024Electrical System12,191 vehicles

    Electrical system:wiring

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.

    Risk: An overheated ground cable increases the risk of a fire.

    Remedy: Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2024MMNNNN.

  2. NHTSA 23V880000Dec 21, 2023Fuel System79,676 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024, August 9, 2024, October 1, 2024, and December 2, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of NHTSA recall number 23V-445.

  3. NHTSA 23V445000Jun 26, 2023Fuel System143,551 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

See all 5 recalls for the 2022 Mercedes-Benz E 450 →

2022 Mercedes-Benz E 450 fuel economy and fuel cost

City
22 MPG
Highway
29 MPG
Combined
24.5 MPG
Annual fuel cost (EPA)
$3,250
15,000 mi/yr
Fuel
Premium
Current regular gas
$4.32/gal
national avg.

EPA figures; median across configurations of this model year. Estimate your own cost with the fuel cost calculator.

2022 compared with other E 450 years

Complaint Index by model year (0 = fewest issues, 100 = most)0255075100201920202021202220232024
Complaint Index: 0 = fewest issues, 100 = most, relative to other years of this model. Avoid Caution Good Best
YearVerdictIndexComplaintsRecallsMPG
2020Caution608722.5
2021Caution2071425
2022Good4011524.5
2023Avoid8017424.5
2024No verdict02425

All Mercedes-Benz E 450 years: best and worst →

Frequently asked questions

Is the 2022 Mercedes-Benz E 450 reliable?
Based on NHTSA owner complaints and recalls, the 2022 E 450 has a Good verdict relative to other years, with a complaint index of 40 and 11 complaints, ranking 4th out of 6 model years.
What problems does the 2022 Mercedes-Benz E 450 have?
The top reported area is the Electrical System, covering 36% of complaints, including 48-volt system failures and backup camera issues. Fuel System, Brakes, and Suspension issues were also reported.
Does the 2022 Mercedes-Benz E 450 have any recalls?
Yes, NHTSA lists 5 recall campaigns for the 2022 E 450, covering the 48-volt ground cable, fuel pump (two separate campaigns), a 12-volt battery securing issue, and a steering-wheel DISTRONIC software error.
How does the 2022 E 450 compare to other model years?
With a complaint index of 40, the 2022 E 450 ranks better than 2019 (100, Avoid), 2020 (60, Caution), and 2023 (80, Avoid), but worse than 2021 (20, Caution) and 2024 (0).
What is the fuel economy of the 2022 Mercedes-Benz E 450?
EPA rates the 2022 E 450 at 24.5 mpg combined (22 city / 29 highway), with an estimated annual fuel cost of $3,250.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.