YearToAvoid

2022 Mercedes-Benz E 450 Problems, Recalls & Reliability

Verdict

Good

Complaint Index

40/100

#4 most-complained of 6 E 450 years

The 2022 Mercedes-Benz E 450 has 11 NHTSA complaints, 5 recalls, and a Complaint Index of 40, ranking 4th worst out of 6 model years. It earns a "Good" rating relative to other E 450 years, well behind the 2021 (index 20, Best) but ahead of 2019, 2020, and 2023.

Complaints
11
Recalls
5
Crashes / fires
0 / 0
Injuries / deaths
0 / 0
NHTSA overall rating
Not rated
EPA combined MPG
24.5
22 city / 29 hwy

Top 2022 Mercedes-Benz E 450 problems

NHTSA owner complaints by component group. Groups with 15+ complaints have their own page.

  1. Electrical System4 (36%)
  2. Fuel System3 (27%)
  3. Brakes2 (18%)
  4. Suspension, Wheels & Tires2 (18%)
  5. Engine1 (9%)
  6. Collision Avoidance & Cameras1 (9%)
  7. Steering1 (9%)
  8. Structure & Body1 (9%)
  9. Transmission & Powertrain1 (9%)

What owners report

  • Automatic emergency braking triggers unexpectedly on ordinary road surfaces, slamming on the brakes with no obstacle present.
  • The backup camera fails to engage in reverse, leaving a blank screen.
  • Owners report sudden full-power braking followed by a loud popping sound and total loss of power from the engine compartment.
  • Vehicles under the fuel pump recall (23V445000) sat for months without available replacement parts despite dealer notification.
  • A 48-volt battery malfunction warning appears on the dashboard, followed by a red warning light and deceleration within about 30 seconds.
  • An underbody splash shield covering the transmission detached at highway speed and dragged along the road.
2022 Mercedes-Benz E 450 complaints: complaints filed per month3Apr 2022Aug 2022May 2023Nov 2023Dec 2024
16 complaints filed with NHTSA from Apr 2022 to Mar 2026; peak Jun 2022 (3).

2022 Mercedes-Benz E 450 recalls

5 NHTSA recall campaigns list this model year.

  1. NHTSA 24V100000Feb 9, 2024Electrical System12,191 vehicles

    Electrical system:wiring

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.

    Risk: An overheated ground cable increases the risk of a fire.

    Remedy: Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2024MMNNNN.

  2. NHTSA 23V880000Dec 21, 2023Fuel System79,676 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024, August 9, 2024, October 1, 2024, and December 2, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of NHTSA recall number 23V-445.

  3. NHTSA 23V445000Jun 26, 2023Fuel System143,551 vehicles

    Fuel system, gasoline:delivery:fuel pump

    Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

    Risk: A loss of drive power can increase the risk of a crash.

    Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

See all 5 recalls for the 2022 Mercedes-Benz E 450 →

2022 Mercedes-Benz E 450 fuel economy and fuel cost

City
22 MPG
Highway
29 MPG
Combined
24.5 MPG
Annual fuel cost (EPA)
$3,250
15,000 mi/yr
Fuel
Premium
Current regular gas
$4.32/gal
national avg.

EPA figures; median across configurations of this model year. Estimate your own cost with the fuel cost calculator.

2022 compared with other E 450 years

Complaint Index by model year (0 = fewest issues, 100 = most)0255075100201920202021202220232024
Complaint Index: 0 = fewest issues, 100 = most, relative to other years of this model. Avoid Caution Good Best
YearVerdictIndexComplaintsRecallsMPG
2020Caution608722.5
2021Best2071425
2022Good4011524.5
2023Avoid10017424.5
2024No verdict02425

All Mercedes-Benz E 450 years: best and worst →

Frequently asked questions

Is the 2022 Mercedes-Benz E 450 reliable?
NHTSA lists 11 complaints and 5 recalls for the 2022 E 450, giving it a Complaint Index of 40. That ranks 4th worst out of 6 model years, earning a "Good" verdict relative to other E 450 years.
What are the main problem areas for the 2022 E 450?
Electrical System complaints lead at 36% of all complaints (4 of 11), followed by Fuel System at 27% and Brakes and Suspension each at 18%.
Does the 2022 E 450 have a recall?
Yes, NHTSA lists 5 recalls for the 2022 E 450, covering the 48-volt ground cable connection, fuel pump replacement (two separate campaigns), a 12V trunk battery securing issue, and a steering wheel heating software update.
How does the 2022 E 450 compare to the 2021 E 450?
The 2021 E 450 has a Complaint Index of 20 and a "Best" verdict, while the 2022 model's index is 40 with a "Good" verdict, making 2021 the stronger year of the two.
What mileage do problems typically show up at on the 2022 E 450?
NHTSA data shows a median mileage at failure of 400 miles for reported Electrical System and Engine complaints on the 2022 E 450.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.