YearToAvoid

2006 Ford E-350 Engine Problems

NHTSA has 18 owner complaints about engine problems in the 2006 Ford E-350, 34% of all 53 complaints for this model year. That is #2 highest engine complaint count among 21 E-350 model years. These complaints report 2 crashes, 2 fires, and 1 injury. Median mileage at failure: 46,874 miles.

Engine complaints
18
34% of 53
Crashes reported
2
Fires reported
2
Injuries reported
1
Median mileage
46,874 mi
Related recalls
0

When 2006 Ford E-350 engine complaints were filed

First complaint May 15, 2006, latest Nov 3, 2016.

2006 Ford E-350 engine complaints: complaints filed per month2May 2006Sep 2006Jul 2007May 2010Apr 2013Oct 2014
18 complaints filed with NHTSA from May 2006 to Nov 2016; peak Aug 2006 (2).

Engine recalls for the 2006 Ford E-350

No safety recalls on record for this model year.

Engine complaints by E-350 model year

Raw complaint counts per model year; newer years have had less time to accumulate complaints.

  1. 200521 (38%)
  2. 200618 (34%)
  3. 20074 (22%)
  4. 20085 (13%)
  5. 20092 (20%)
  6. 20102 (12%)
  7. 20111 (5%)
  8. 20124 (25%)
  9. 20133 (23%)
  10. 20144 (24%)
  11. 20150 (0%)
  12. 20160 (0%)
  13. 20172 (15%)
  14. 20180 (0%)
  15. 20190 (0%)
  16. 20200 (0%)
  17. 202111 (50%)
  18. 20221 (7%)
  19. 20231 (50%)
  20. 20240 (0%)
  21. 20250 (0%)

Frequently asked questions

Does the 2006 Ford E-350 have engine problems?
NHTSA has 18 owner complaints about the engine in the 2006 Ford E-350, 34% of all complaints for this model year, including 2 that report a crash. Median mileage at failure is 46,874 miles.
Which Ford E-350 year has the most engine complaints?
The 2005 Ford E-350 has the most engine complaints (21), compared with 18 for the 2006.
Is there a engine recall for the 2006 Ford E-350?
No NHTSA recall campaign for the 2006 Ford E-350 is classified under engine. Complaints alone do not trigger a recall; check the full recall list and your VIN.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.