YearToAvoid

2006 Mercedes-Benz E350 Transmission & Powertrain Problems

NHTSA has 37 owner complaints about transmission problems in the 2006 Mercedes-Benz E350, 9% of all 399 complaints for this model year. That is the highest transmission complaint count among 19 E350 model years. These complaints report 1 crash and 1 injury. Median mileage at failure: 72,740 miles.

Transmission & Powertrain complaints
37
9% of 399
Crashes reported
1
Fires reported
0
Injuries reported
1
Median mileage
72,740 mi
Related recalls
0

When 2006 Mercedes-Benz E350 transmission complaints were filed

First complaint Aug 26, 2005, latest Aug 29, 2024.

2006 Mercedes-Benz E350 transmission & powertrain complaints: complaints filed per month2Aug 2005Sep 2008Oct 2011Oct 2012Jul 2014Jul 2015Jan 2018
37 complaints filed with NHTSA from Aug 2005 to Aug 2024; peak Mar 2015 (2).

Transmission & Powertrain recalls for the 2006 Mercedes-Benz E350

No safety recalls on record for this model year.

Transmission & Powertrain complaints by E350 model year

Raw complaint counts per model year; newer years have had less time to accumulate complaints.

  1. 20050 (0%)
  2. 200637 (9%)
  3. 200721 (6%)
  4. 20085 (3%)
  5. 20092 (3%)
  6. 201014 (8%)
  7. 20116 (3%)
  8. 201210 (5%)
  9. 20137 (4%)
  10. 201415 (5%)
  11. 20151 (3%)
  12. 20165 (10%)
  13. 20170 (0%)
  14. 20201 (13%)
  15. 20213 (23%)
  16. 20221 (13%)
  17. 20230 (0%)
  18. 20240 (0%)
  19. 20250 (0%)

Frequently asked questions

Does the 2006 Mercedes-Benz E350 have transmission problems?
NHTSA has 37 owner complaints about the transmission in the 2006 Mercedes-Benz E350, 9% of all complaints for this model year, including 1 that report a crash. Median mileage at failure is 72,740 miles.
Which Mercedes-Benz E350 year has the most transmission complaints?
The 2006 Mercedes-Benz E350 has the most transmission complaints (37), compared with 37 for the 2006.
Is there a transmission recall for the 2006 Mercedes-Benz E350?
No NHTSA recall campaign for the 2006 Mercedes-Benz E350 is classified under transmission & powertrain. Complaints alone do not trigger a recall; check the full recall list and your VIN.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.