YearToAvoid

2006 Mercedes-Benz E350 Fuel System Problems

NHTSA has 219 owner complaints about fuel system problems in the 2006 Mercedes-Benz E350, 55% of all 399 complaints for this model year. That is #2 highest fuel system complaint count among 19 E350 model years. These complaints report 2 crashes, 5 fires, and 2 injuries. Median mileage at failure: 88,950 miles.

Fuel System complaints
219
55% of 399
Crashes reported
2
Fires reported
5
Injuries reported
2
Median mileage
88,950 mi
Related recalls
0

When 2006 Mercedes-Benz E350 fuel system complaints were filed

First complaint Feb 2, 2010, latest Mar 19, 2023.

2006 Mercedes-Benz E350 fuel system complaints: complaints filed per quarter232010 Q12012 Q32013 Q42015 Q12016 Q22017 Q32020 Q12021 Q4
219 complaints filed with NHTSA from 2010 Q1 to 2023 Q1; peak 2013 Q3 (23).

Fuel System recalls for the 2006 Mercedes-Benz E350

No safety recalls on record for this model year.

Fuel System complaints by E350 model year

Raw complaint counts per model year; newer years have had less time to accumulate complaints.

  1. 20055 (33%)
  2. 2006219 (55%)
  3. 2007253 (72%)
  4. 200886 (50%)
  5. 200933 (52%)
  6. 201020 (11%)
  7. 201132 (14%)
  8. 201235 (16%)
  9. 201311 (7%)
  10. 201436 (13%)
  11. 20152 (6%)
  12. 20164 (8%)
  13. 20172 (29%)
  14. 20202 (25%)
  15. 20213 (23%)
  16. 20221 (13%)
  17. 20230 (0%)
  18. 20240 (0%)
  19. 20250 (0%)

Frequently asked questions

Does the 2006 Mercedes-Benz E350 have fuel system problems?
NHTSA has 219 owner complaints about the fuel system in the 2006 Mercedes-Benz E350, 55% of all complaints for this model year, including 2 that report a crash. Median mileage at failure is 88,950 miles.
Which Mercedes-Benz E350 year has the most fuel system complaints?
The 2007 Mercedes-Benz E350 has the most fuel system complaints (253), compared with 219 for the 2006.
Is there a fuel system recall for the 2006 Mercedes-Benz E350?
No NHTSA recall campaign for the 2006 Mercedes-Benz E350 is classified under fuel system. Complaints alone do not trigger a recall; check the full recall list and your VIN.

Sources: NHTSA Office of Defects Investigation complaint and recall databases; U.S. EPA fuel economy data; NHTSA 5-Star Safety Ratings. Complaints are unverified owner reports.

Data updated Sep 24, 2026. Read the methodology and data sources. The Complaint Index is based on NHTSA owner complaints and recalls; it is not a reliability rating.